Jardiance is an oral diabetes medication manufactured by Boehringer Ingelheim Pharmaceuticals, Inc. that was approved by the United States Food and Drug Administration (FDA) in 2014. It is classified as a sodium-glucose co-transporter 2 (SGLT-2) inhibitor. SGLT-2 inhibitors are sometimes referred to as “flozins” or “gliflozins” because of the common ending in the generic names of this class.
Currently, there is currently no generic version of Jardiance available. It is not known when the first generic version of Jardiance will become available but based on the patents and regulatory protections it appears that the earliest date for generic entry will be Feb. 24, 2025. Learn more about the earliest potential release date for generic Jardiance and options to save money on this medication.
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What is Jardiance (empagliflozin)?
Jardiance is an SGLT-2 inhibitor that is FDA-approved to:
- Reduce the risk of cardiovascular death and hospitalization for heart failure in adults with heart failure.
- Reduce the risk of cardiovascular death from heart attack and stroke in adults with type 2 diabetes mellitus (T2DM) and cardiovascular disease.
- Improve blood sugar levels along with diet and exercise in adults with T2DM
Jardiance should not be used if you have type 1 diabetes mellitus (T1DM) as it can increase your risk of diabetic ketoacidosis (increased ketones in your blood or urine). It should also be avoided if you have chronic kidney disease (CKD) and are on dialysis.
Jardiance works by inhibiting the transporter (SGLT-2) that is responsible for reabsorbing the majority of glucose filtered by your kidney. By inhibiting SGLT-2, Jardiance decreases the amount of glucose that is reabsorbed and increases the amount that is excreted out through your urine.
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What dosage forms and strengths are available for Jardiance?
- 10 mg tablet
- 25 mg tablet
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Is there a cheaper alternative to Jardiance?
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There are several other prescription medications you can take to help improve your glycemic control if you cannot take Jardiance. These medications have different strengths, dosages, and indications.
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Is there a generic available for Jardiance?
No, currently there is no generic version of Jardiance available. However, you can save on brand-name drugs like Jardiance through NiceRx if eligible for assistance.
When will generic Jardiance become available?
The exact date when a generic of Jardiance will be released is not known. However, the drug patents for Jardiance are expected to expire in February 2025, which is the earliest a Jardiance generic could become available for sale. This may change due to patent challenges or generic licensing by the drug manufacturer.
How do you take Jardiance?
Jardiance is an oral diabetes medicine that is used with a proper diet and exercise program to control high blood sugar in people with T2DM. It is a tablet that is taken by mouth once in the morning each day, with or without food. Your doctor may adjust your dose based on your blood glucose levels. You should not change your dose or stop taking this medication without discussing it with them first. If you miss a dose of Jardiance, take it as soon as you remember. If it is almost time for your next dose, skip the dose you missed and go back to your regular schedule. Do not take extra doses of Jardiance to make up for a missed dose.
What should you tell your doctor before starting Jardiance?
You should not take this medication if you have a hypersensitivity to empagliflozin or any of the inactive ingredients in Jardiance or if you are on dialysis.
You should take Jardiance with caution if you have certain medical conditions, including:
- Heart disease or low blood pressure (hypotension)
- Kidney problems or decreased kidney function
- Liver problems
- History of infection of the penis or vagina
- History of urinary tract infections
- Scheduled surgery
- Change in diet or amount of food you are eating
- Problems with your pancreas or pancreatic surgery
- Are a chronic alcohol drinker or you binge drink
- Type 1 diabetes
- Are currently pregnant or are planning on becoming pregnant as this medication may harm your unborn baby
- Are currently breastfeeding or planning to breastfeed
Jardiance side effects
The most common side effects of Jardiance seen in clinical trials include:
- Urinary tract infections (UTIs)
- Yeast infections
- Upper respiratory tract infection
- Increased cholesterol
- Increased urination
- Male genital yeast or fungal infections
- Nausea
- Weight loss
- Joint pain
- Dizziness or lightheadedness
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Jardiance can sometimes cause serious side effects such as:
- Serious allergic reactions including life-threatening anaphylaxis (hives, swelling of the throat or tongue, and trouble breathing)
- Low blood sugar (hypoglycemia), especially if taken with a sulfonylurea
- Kidney problems
- Volume depletion, especially in patients with reduced kidney function, elderly patients, or patients on loop diuretics (water pills)
Speak with your healthcare professional about the possible drug interactions with any other prescription drugs, over-the-counter products, vitamins, and supplements you are taking. These are not all of the possible side effects of Jardiance. You should always seek medical advice for any questions or concerns relating to your medical condition or treatment. You can report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
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What is the average monthly cost of Jardiance?
The estimated cost for #30 (30-day supply) tablets of Jardiance 10mg is almost $700 without insurance.
How long does it take Jardiance to work?
According to the drug manufacturer, it can take up to 24 weeks before you see results with Jardiance, so it’s important to take it daily. As with all medications, your results may vary.
What is the difference between Jardiance and Invokana?
Jardiance and Invokana are both used along with diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Jardiance is also approved to reduce the risk of cardiovascular death in adults with type 2 diabetes mellitus or heart failure. Both medications are classified as SGLT 2 inhibitors that are taken by mouth once a day. They both commonly cause side effects such as vaginal yeast infection, genital yeast infection in men, and increased cholesterol levels. While they have not been compared directly, both medications have been shown to be effective in lowering HbA1c levels, fasting and postprandial (after a meal) glucose levels, weight, and systolic blood pressure.
What drug is comparable to Jardiance?
There are a number of medications available to manage a diagnosis of type 2 diabetes mellitus if Jardiance is not the right medication for you. These medications should be used along with a diet and exercise program developed by your doctor or diabetes care team.
Some alternative oral medications that your doctor may prescribe include:
- Invokana (canagliflozin), an oral tablet taken once a day
- Farxiga (dapagliflozin), an oral tablet taken once a day
- Steglatro (ertugliflozin), an oral tablet taken once a day
- Glucophage (metformin), an oral tablet taken up to 3 times a day
- Tradjenta (linagliptin), an oral tablet taken once a day
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