1. Helps rebuild the dermal matrix with highly bioavailable building blocks Collagen, hyaluronic acid (HA), and chondroitin sulfate are essential for the healthy structure and function of the skin dermis. As one ages, the amounts of these components decrease which leads to the disorganization or collapse of the dermal matrix. Clinical studies demonstrate that supplementing with BioCell Collagen promotes skin beauty from within. Collagen provides tensile strength of the dermal matrix in which ground substances such as hyaluronic acid are interweaved. Additionally, increasing the density of dermal fibroblasts, which are responsible for biosynthesis of structural components for the dermal network, can also contribute to youthful appearance of skin.

2. Enhances skin hydration, turgidity, and inhibition of hyaluronidase Maintaining a proper amount of HA is critical for healthy skin structure and turgidity because HA is responsible for holding water in the skin dermis. HA and collagen decrease with age, resulting in dermal dehydration, skin-sagging, and wrinkle formation. BioCell Collagen supplies highly bioavailable HA to attenuate the effect of the loss caused by natural deterioration or photo-aging. Human subjects who took a daily dose of BioCell Collagen saw HA levels increase 60-fold in their blood during 28 days of the study period.

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HA levels are maintained by the coordinated action of HA syntheses and hyaluronidases. Hyaluronidase degrades HA in response to a number of normal or pathological stimuli including aging and inflammation. BioCell Collagen has been shown to inhibit hyaluronidase. Thus, BioCell Collagen can tackle an important molecular player responsible for aging-associated dehydration while replenishing the loss of the various essential structural components of the skin dermis. In 2011, BioCell Technology performed a ground-breaking human skin study and demonstrated that daily ingestion of BioCell Collagen for 12 weeks led to a significant reduction of facial lines and wrinkles together with enhancement of hydration and stimulation of collagen biosynthesis likely from dermal fibroblasts. It also led to an increase in hemoglobin in the facial skin tissue suggesting enhanced microcirculation of blood in the dermis. The majority of the study participants experienced improved skin texture as well as enhanced moisture and reduced scaling in their face. The study outcome was published in The Clinical Interventions in Aging (2012). (http://www.ncbi.nlm.nih.gov/pubmed/22956862)

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