HomeWHYWhy Is Traumeel Being Discontinued

Why Is Traumeel Being Discontinued

1. St Laurent G 3rd, Seilheimer B, Tackett M, et al. Deep Sequencing Transcriptome Analysis of Murine Wound Healing: Effects of a Multicomponent, Multitarget Natural Product Therapy-Tr14. Front Mol Biosci. 2017;4:57. Published 2017 Aug 17. doi:10.3389/fmolb.2017.00057

2. Baillif V, Guigné C, Wanecq E, et al. A multicomponent medication (HE-100) promotes inflammation resolution. Poster presented at: Resolution of Inflammation, Infection and Tissue Regeneration; June 25-26, 2018; New York, USA. Link to abstract: https://www.ambiotis.com/images/temoignages/NYAS-2018-submitted-abstract.pdf

3. Porozov S, Cahalon L, Weiser M, Branski D, Lider O, Oberbaum M. Inhibition of IL-1beta and TNF-alpha secretion from resting and activated human immunocytes by the homeopathic medication Traumeel S. Clin Dev Immunol. 2004;11(2):143-149. doi:10.1080/10446670410001722203

4. González de Vega C, Speed C, Wolfarth B, González J. Traumeel vs. diclofenac for reducing pain and improving ankle mobility after acute ankle sprain: a multicentre, randomised, blinded, controlled and non-inferiority trial. Int J Clin Pract. 2013;67(10):979-989. doi:10.1111/ijcp.12219

5. Birnesser H, Oberbaum M, Klein, P Weiser M. The homeopathic preparation Traumeel S compared with NSAIDs for symptomatic treatment of epicondylitis. J Musculoskelet Res. 2004;8:119-128. doi.org/10.1142/S0218957704001284

6. Schneider C, Klein P, Stolt P, Oberbaum M. A homeopathic ointment preparation compared with 1% diclofenac gel for acute symptomatic treatment of tendinopathy. Explore (NY). 2005;1(6):446-452. doi:10.1016/j.explore.2005.08.010

7. St Laurent G, Toma I, Tackett M, et al. Differential effects of Tr14 versus diclofenac on pro-resolving lipid mediators revealed by rnaseq. [Abstract AB0080]. Ann Rheum Dis. 2018;77(Suppl): A1237

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8. St Laurent G, Toma I, Seilheimer B, et al. Differential effects of Tr14 versus diclofenac on cox/lox pathways revealed by rnaseq. . [Abstract THU0021. Ann Rheum Dis. 2018;77(Suppl): A328

9. Muders K, Pilat C, Deuster V, et al. Effects of Traumeel (Tr14) on Exercise-Induced Muscle Damage Response in Healthy Subjects: A Double-Blind RCT. Mediators Inflamm. 2016;2016:1693918. doi:10.1155/2016/1693918

10. Muders K, Pilat C, Deuster V, et al. Effects of Traumeel (Tr14) on recovery and inflammatory immune response after repeated bouts of exercise: a double-blind RCT. Eur J Appl Physiol. 2017;117(3):591-605. doi:10.1007/s00421-017-3554-8

11. Cesnulevicius K. The bioregulatory approach to work-related musculoskeletal disorders: using the multicomponent ultra low-dose medication Traumeel to target the multiple pathophysiological processes of the disease. Altern Ther Health Med. 2011;17(suppl 2):S8-S17.

12. Martel-Pelletier J, Pelletier JP, Fahmi H. Cyclooxygenase-2 and prostaglandins in articular tissues. Semin Arthritis Rheum. 2003;33(3):155-167. doi:10.1016/s0049-0172(03)00134-3

13. Schneider C, Schneider B, Hanisch J, van Haselen R. The role of a homoeopathic preparation compared with conventional therapy in the treatment of injuries: an observational cohort study. Complement Ther Med. 2008;16(1):22-27. doi:10.1016/j.ctim.2007.04.004

14. Zenner S, Weiser M. Orale Therapie traumatischer, entzündlicher und degenerativer Affektionen mit einem Homöopathikum [Oral Treatment of Traumatic, Inflammatory, and Degenerative Conditions with a Homeopathic Remedy]. Biologische Medizin. 1996;XXV(5):211- 216. (English translation available in: Biomed Ther. 1997;XV(1):22-26).

15. Zenner S, Metelmann H. Therapieerfahrungen mit Traumeel S Salbe: Ergebnisse einer multizentrischen Anwendungsbeobachtung an 3,422 Patienten [Therapy Experience with a Homeopathic Ointment: Results of Drug Surveillance Conducted on 3,422 Patients]. Biologische Medizin. 1992;XXI(5):341-9. (English translation available in: Biol Ther. 1994; XII(3):204-211).

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16. Zenner S, Metelmann H. Einsatzmöglichkeiten von Traumeel S Injektionslösung: Ergebnisse einer multizentrischen Anwendungsbeobachtung an 3241 Patienten [Application Possibilities of Traumeel S Injection Solution: Results of a Multicentric Drug Monitoring Trial Conducted on 3,241 Patients]. Biologische Medizin. 1992;XXI(3):207-219. (English translation available in: Biol Ther. 1992;X(4):301-310)

17. Vuurberg G, Hoorntje A, Wink LM, et al. Diagnosis, treatment and prevention of ankle sprains: update of an evidence-based clinical guideline. Br J Sports Med. 2018;52(15):956. doi:10.1136/bjsports-2017-098106

18. Stovitz SD, Johnson RJ. NSAIDs and musculoskeletal treatment: what is the clinical evidence? Phys Sportsmed. 2003;31(1):35-52. doi:10.3810/psm.2003.01.160

19. Zell J, Connert WD, Mau J, Feuerstake G. Behandlung von akuten Sprunggelenksdistorsionen: Doppelblindstudie zum Wirksamkeitsnachweis eines homoopathischen Salbenpraparats. [Treatment of acute sprains of the ankle: a controlled doubleblind trial to test the effectiveness of a homeopathic ointment]. Fortschr Med 1988;106(5):96-100. English translation available in Biol Ther. 1989;7(1):1-6.

20. Böhmer D, Ambrus P. Treatment of sports injuries with Traumeel ointment: a controlled double-blind study. Biol Ther. 1992;10(4):290-300.

21. Traumeel® Summary of Product Characteristics.

22. Arora S, Harris T, Scherer C. Clinical safety of a homeopathic preparation. Biomed Ther. 2000;18(2):222-225.

23. Griffin M. Con: nonsteroidal anti-inflammatory drugs should not be routinely administered for postoperative analgesia after cardiac surgery. J Cardiothorac Vasc Anesth. 2000;14(6):735‐738. doi:10.1053/jcan.2000.18591.

24. Langendorf EK, Klein A, Rommens PM, Drees P, Ritz U, Mattyasovszky SG. Calf Blood Compound (CFC) and Homeopathic Drug Induce Differentiation of Primary Human Skeletal Muscle Cells. Int J Sports Med. 2019;40(12):803-809. doi:10.1055/a-0915-2306

25. Beispielliste zulaessiger Medicamente 2021. Accessed April 2021. https://www.nada.de/medizin/im-krankheitsfall

26. World Anti-Doping Code International Standard Prohibited List 2021. Accessed April 2021. https://www.wada-ama.org/en/resources/sciencemedicine/prohibited-list-documents

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27. Bisciotti GN, Volpi P, Amato M, et al. Italian consensus conference on guidelines for conservative treatment on lower limb muscle injuries in athlete. BMJ Open Sport Exerc Med. 2018;4(1):e000323. Published 2018 May 24. doi:10.1136/bmjsem-2017-000323

28. Del Valle Soto M, Díaz JF, Marqueta PM, et al. Consenso sobre utilización de la vía parenteral en el deporte. Utilización de medicación homeopática, terapias biológicas y biorreguladoras. Documento de Consenso de la Federación Española de Medicina del Deporte [Consensus on use of parenteral therapy in sports. Use of homeopathic medication, biological and bioregulatory therapy. Document of consensus of the Spanish Federation of Sports Medicine] Arch Med Deporte. 2013;30(1):8-13

29. Lussignoli S, Bertani S, Metelmann H, Bellavite P, Conforti A. Effect of Traumeel S, a homeopathic formulation, on blood-induced inflammation in rats. Complement Ther Med. 1999;7(4):225-230. doi:10.1016/s0965-2299(99)80006-5

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